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Tzield binds to certain cells in the immune system and delays progression to stage 3 type 1 diabetes. Tzield can turn off immune cells that attack insulin-producing cells, while increasing the proportion of cells that help moderate the immune response. Tzield is administered by intravenous infusion once daily for 14 consecutive days.
The safety and efficacy of Tzield were evaluated in a randomized, double-blind, event-driven, placebo-controlled study in 76 patients with stage 2 type 1 diabetes. In the study, patients randomly received either Tzield or placebo once daily by intravenous infusion for 14 days. The primary measure of efficacy was the time from randomization to the development of a diagnosis of stage 3 type 1 diabetes. Study results showed that during a median follow-up of 51 months, 45% of the 44 patients who received Tzield were subsequently diagnosed with stage 3 type 1 diabetes, compared with 72% of the 32 patients who received placebo. The median time from randomization to diagnosis of stage 3 type 1 diabetes was 50 months for patients receiving Tzield and 25 months for those receiving placebo. This represents a statistically significant delay in the development of stage 3 type 1 diabetes.
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Take the missed dose as soon as you remember it. However, if it is near the time for your next dose, skip the missed dose and continue taking your regular dose. Do not double the dose to make up for a missed dose.What side effects may I notice from this medicine?
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, has had a seizure, has difficulty breathing, or cannot be awakened, call emergency services immediately at 911.What other important information should I know?
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Take the missed dose as soon as you remember it. However, if it is near the time of your next dose, skip the missed dose and continue taking your regular dose. Do not double the dose to make up for a missed dose.What side effects may I notice from this medicine?
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, has had a seizure, has difficulty breathing, or cannot be awakened, call emergency services immediately at 911.What other important information should I know?
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Generally, diabetes medications in the class of glucagon-like peptide type 1 agonists are given by injection on a daily or weekly basis and include the following:
These drugs mimic the action of a hormone called glucagon-like peptide type 1. When blood glucose levels begin to rise after eating, these drugs stimulate the body to produce more insulin. The extra insulin helps lower blood glucose levels.
In addition to helping to control blood glucose and increase weight loss, inhibitors of glucagon-like peptides type 1 and sodium-glucose cotransporter type 2 appear to have other significant benefits. Research has found that some medications in these groups may reduce the risk of heart disease, such as heart failure, stroke and kidney disease. People receiving these medications have seen improvements in their blood pressure and cholesterol levels, but it is not certain whether these benefits are due to the medication or to weight loss.